Oral bacteria predict gastric and colorectal cancer
Researchers analyzed paired oral and fecal microbiomes from 507 people in South Korea and sequenced 1,010 samples to create a mouth-to-feces (MF) transmission index that measures how much of the gut microbiome derives from oral bacteria. Mean MF values were higher in gastric (3.63) and colorectal cancer (3.09) than in healthy controls (1.19). Machine learning models based on MF-transmitted bacteria detected colorectal cancer with AUCs around 0.82 and validated across international cohorts, and MF-based oral and fecal models outperformed FOBT in one external comparison; limitations include unresolved causality and the need for broader validation.
MF index detects colorectal cancer with higher sensitivity than FOBT
Context
Scientists measured oral and stool bacteria in people with and without cancer. They found more mouth bacteria in the gut of people with gastric and colorectal cancer. Next steps could include further validation and development of an…
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