Study finds shared cancer genes in cats and humans
International Business Times, Singapore Edition
An international team sequenced tumor samples from nearly 500 domestic cats across five countries and mapped mutations that drive cancer, finding many overlaps with human cancer genes. Mammary tumors were notable, with more than 50% showing FBXW7 mutations, a gene also linked to human breast cancer. Researchers also observed similarities across blood, bone, lung, skin, gastrointestinal and central nervous system cancers, and tested chemotherapy responses in cat mammary tumor tissue, with some drugs working better on FBXW7-mutant samples. The work creates a genomic resource to support cross-species and precision oncology studies, while noting that clinical validation is still needed.
Cat and human tumors share many cancer-driving genes, including FBXW7.
Context
Researchers collected and sequenced tumor tissue that veterinarians had already gathered. They compared genetic changes across many feline tumor types. Next steps could include testing whether tissue findings hold true in living animals…
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