AstraZeneca drug improves survival in CLDN18.2 gastric cancer trial
AstraZeneca reported that sonesitatug vedotin (Sone‑Ve) improved overall survival in the Phase III CLARITY‑Gastric01 trial for CLDN18.2‑positive advanced gastric, gastroesophageal junction and esophageal adenocarcinomas. The trial met the dual primary endpoint of overall survival in third‑and‑later line treatment and a key secondary overall survival endpoint in the combined second‑and‑later line population, while blinded independent review progression‑free survival did not reach statistical significance in the second‑and‑later line cohort. The global trial randomized patients at two dosing levels versus investigator's choice across 175 centers in 19 countries, and results will be presented and shared with regulators.
Sone‑Ve improved overall survival in CLDN18.2‑positive gastric cancers.
Context
A Phase III trial tested Sone‑Ve in advanced gastric and related cancers with CLDN18.2 expression. The trial showed overall survival benefit in some settings but not progression‑free survival in another. Results will be presented and sent…
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