Researchers identify vulnerable stage in brain micrometastases
Scientists at the Spanish National Cancer Research Centre (CNIO) report a previously unknown transient stage, a proliferative pause, during which brain micrometastases are especially vulnerable. Using mouse models and human tissue from the PEACE and RENACER consortia, the team identified molecular mechanisms that permit survival during this pause and showed that three drugs, two already approved for other indications, eliminated micrometastases in experimental systems. The findings, published in Cancer Cell, validate targets in human samples, support testing preventive therapies to avoid relapse after surgery, and set the stage for medium-term clinical trials and biomarker development.
A transient proliferative pause makes brain micrometastases drug-vulnerable.
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Researchers worked on this problem for more than six years. They published their…
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