Blood marker ratio distinguishes bacterial from viral infections in infants
At the European Emergency Medicine Congress, investigators from IRCCS Istituto Giannina Gaslini presented a small study of 60 infants assessing a flow cytometry test that compares CD64 and CD169 levels. The researchers combined these markers into a ratio that averaged 16.22 for confirmed bacterial infections, 0.33 for viral infections and 1.10 for no infection. The test showed 100% sensitivity and 96.6% specificity in this cohort. The assay currently needs specialist flow cytometry and is not a bedside test; researchers plan to expand to 75 infants and run a multicentre DISCERN study in 300–500 babies to validate and develop a point-of-care format.
A CD64/CD169 ratio accurately separated bacterial and viral infections in 60 infants.
Context
A fever in babies under three months is treated as an emergency because infections can become life threatening. Clinicians need ways to tell bacterial from viral infections to guide antibiotics and invasive tests. This study tested a flow…
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