Scientists map gene activity in prefrontal cortex
Scientists created a cell-level map of gene activity in the prefrontal cortex by analyzing nuclei from more than 6.3 million brain cells taken from 1,494 donors aged infancy to 108, including people with Alzheimer’s, Parkinson’s, Lewy body and vascular dementia, schizophrenia and bipolar disorder. The nine studies linked inherited genetic risk to specific genes and cell types, mapped regulation of over 14,000 genes, and found shared disease pathways in neurons, microglia and blood-vessel biology; they also identified an age transition near 24 and weaker daily clock gene coordination in older adults, guiding target selection and individualized treatment research.
Map links gene activity to disease pathways across multiple brain disorders
Context
Researchers published nine linked studies that mapped gene activity in the prefrontal cortex. The work used samples from 1,494 donors and many disorders. Next steps could include testing the mapped targets and studying whether restoring…
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