Light speeds antibody detection of colorectal cancer biomarker
Researchers at Osaka Metropolitan University used laser irradiation in a light-induced acceleration system (LAC-SYS) to speed antibody-antigen binding and detect the colorectal cancer biomarker CEACAM-5 in blood plasma within minutes. The method used antibody-coated microscopic beads in a tiny flow channel and produced measurable bead assemblies from 5 µL plasma diluted 1,000-fold, detecting CEACAM-5 at 1–10 picograms per milliliter. That sensitivity is one to two orders of magnitude better than conventional immunoassays, and the team also found CEACAM-5 forms nanoscale aggregates; next steps include clinical validation and industry development of portable diagnostics.
Laser-boosted assay detected CEACAM-5 at 1–10 pg/mL.
Context
Scientists added laser light to speed antibody binding and detect CEACAM-5 faster. They found the biomarker as nanoscale aggregates and detected it in tiny plasma samples. Next they will test the method in clinical settings and work with…
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