MIT engineers stabilize RNA vaccine nanoparticles
MIT engineers led by Ana Jaklenec and Robert Langer used an AI algorithm to redesign lipid nanoparticle (LNP) formulations and identify excipient combinations from roughly fifty FDA-approved molecules, producing heat-resistant LNPs. The new formulations remained stable at room temperature for one year and at 37 °C for two months, and vaccines using them produced immune responses in mice comparable to Moderna-like vaccines. The team worked with CSAIL on machine learning and published the findings in Nature Biotechnology. If replicated in humans and scaled, the approach could ease global vaccine distribution, enable microneedle patches, and broaden RNA therapeutic delivery.
AI-designed LNPs kept mRNA stable at room temperature for one year.
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RNA vaccines need very cold storage. Researchers used machine learning to pick…
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