Faecal transplant reduces peanut allergy in some adults
Researchers reported on 5 August in Science Translational Medicine that a faecal transplant pill containing gut bacteria from healthy donors allowed six of 15 highly peanut-allergic adults to tolerate larger amounts of peanut protein four months later. Before treatment, participants reacted to less than 100 mg of peanut protein; after treatment one person tolerated 300 mg and five tolerated 600 mg or more. Most participants took 36 pills in a single day and no severe side effects occurred. Mouse experiments using donor bacteria reproduced protection against a different food allergen, suggesting potential broader applicability but variable human response.
Faecal transplant enabled six of 15 participants to tolerate peanuts.
Context
Researchers previously saw microbiome effects on food allergies in mice. This small human trial tested donor gut bacteria in pill form. Larger trials and different dosing or antibiotic pretreatment could be next steps.
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